胎盘免疫调节多肽遗传毒性和抗突变作用的研究

doi:10.3969/j.issn.1004-616x.1998.03.011

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (3): 167-170.doi: 10.3969/j.issn.1004-616x.1998.03.011

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STUDY ON GENOTOXICITY AND ANTIMUTAGENIC EFFECTS OF THE PLACENTAL IMMUNOREGULATION POLYPEPTIDE

Feng Huigen , LiYanlan , Liu minglin.

Department of Cell Biology Xingxiang Medical College.

Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

Abstract

Abstract: The genotoxicity and antimutagennic effect s of placental immunoregulatioan on polypeptide (PIP) against mutagen2induced chromosomal aberrations and micronuclus formation in human lymphocytes in vit ro and bone marrow of mice were studied. PIP(0. 02 and 0. 03ml/ ml) significantly inhibited spontaneous andγ rays 2induced micronucleus formation and MMC2induced chromosomal aberrations in vit ro. Mentimes PIP(0. 02 and 0. 03ml/ ml) st rongly suppressed also micronucleus formation induced by CP in PCEs of mice. PIP has no genotoxicity and has antimutagenic effect s.

Key words: placental immunoregulation polypeptide, antamutagenic effect s, genotoxicity, chromosome aberration, micronucleus.

Feng Huigen , LiYanlan , Liu minglin.. STUDY ON GENOTOXICITY AND ANTIMUTAGENIC EFFECTS OF THE PLACENTAL IMMUNOREGULATION POLYPEPTIDE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(3): 167-170.

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STUDY ON GENOTOXICITY AND ANTIMUTAGENIC EFFECTS OF THE PLACENTAL IMMUNOREGULATION POLYPEPTIDE

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